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CoSMoS 2007 Presentations

July 30- August 1, 2007
Chapel Hill, NC

Downloads (PDF Files)

Session 1 - Applied Science of Chromatography
Session Chair: Dr. Nelu Grinberg, Boehringer-Ingelheim Pharmaceuticals, Inc.

A New Approach to Retaining Hydrophilic Compounds in HPLC

Professor Joe Pesek, San Jose State University

Ultra-High Pressure Liquid Chromatography

Professor James Jorgenson, University of North Carolina
Mechanistic Aspects of Chiral Discrimination on Polysacharides Phases Nelu Grinberg, Boehringer Ingelheim Pharmaceutical, Inc.
Session 2 - Analyzing Complex Mixtures
Session Chair: Dr. David Stranz, Sierra Analytics, Dr. Ioana Popa-Burke, GlaxoSmithKline
FT-ICR MS Sheds Light on Nature's Complexity Ryan P. Rodgers, Florida State University
Analysis of Perfluorinated Compounds in Complex Environmental and Biological Matrices Mark Strynar, EPA
Comprehensive Metabolomic Profiling for Understanding the Mechanisms of Diabetes and Obesity Michael Muehlbauer, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center
Session 3 - Making Unknowns Known
Session Chair: Melissa Gomez, GlaxoSmithKline
Finding and Identifying Metabolites: Why Resolution and Accurate Mass Matters Kevin Bateman, Merck Frost
Library Searching without Libraries Dan Sweeney, MathSpec
Structure Elucidation and Metabolomics
– Presentation not available
Eric Milgram, Metabolon, Inc.
Session 4 - New Directions in Pharmaceutical Profiling
Session Chair: Dr. Oliver McConnell, Wyeth Research
Impact of ADME/TOX in Drug Discovery: Past, Present and Future Li Di, Wyeth Research
Future Trends in Drug Discovery: The New Drug Metabolism Scientists Dr. Theresa Wilson, Pfizer
Non-Conventional Approach to Solubility Measurement without Filtration by an In Situ UV Fiber Optic Method and the Effects of Excipients on Solubility of Sparingly Soluble Compounds Konstantine Tsinman , pION Inc.
Session 5 - Novel Technologies: "Alternatives In The Face of Chemical Diversity"
Session Chair: Michael Balogh, Waters Corporation

Lead Optimization in a Nano-Droplet: Leveraging Orthogonal Technologies to Improve Throughput for Drug Discovery

Paul Schnier, Amgen
Investigation of the Potential of IMS and FAIMS for the Measurement of Trace Level Impurities in Formulated Drug Products Alice Laures, GlaxoSmithKline
Overcoming Signal Suppression and Other Matrix Effects in LC-MS Using Electron Ionization Professor Achille Cappiello, University of Urbino

Excellence In Science Award Winner
Douglas Kiehl, Eli Lilly & Company