2013 Sessions Downloads

CoSMoS 2013 Presentations

August 11 – August 14, 2013
La Jolla, San Diego, Ca

Downloads (PDF Files unless otherwise noted)

Session 1
Inside the Matrix
— William Farrell, Pfizer, Wolfgang Goetzinger, Amgen, Elizabeth Hamelin, CDC

Explorations With Deep Eutectic Solvents For Chemical Extractions
— Douglas E. Raynie, South Dakota State University

Polar compounds from a polar matrix: three approaches to efficiently and specifically extract alkyl phosphates from biological matrices
— Elizabeth I. Hamelin, CDC, Atlanta, GA

Enabling Histone Methyltransferase Drug Discovery Through a RapidFire-MS Based Assay Platform
— Patrick Bingham, Pfizer
Presentation sponsored by Agilent Corporation

Session 2
Investigations: Making the Unknown Known
—  Douglas Kiehl, Lilly, Justin Stroh, Pfizer

Prohibited Channels: The Analysis and Identification of Diverted Pharmaceuticals
— Heather McCauley, Senior Scientist, FDA, Forensic Chemistry Center

Cultural heritage, art conservation and analytical chemistry: An intersection of art and science
— Daniel Kirby, Conservation Scientist, Straus Center for Conservation and Technical Studies, Harvard/Art Museums

The Case of the Disappearing Mephedrone
— Sabra Botch-Jones, Forensic Toxicology Consulting (fTox)

Session 3
The 2nd Annual Method Development Olympics
— Organizer: Kenneth Fountain, Waters

Gold Medal – Pfizer

Silver Medal – Averica

Bronze Medal – Catalent

Session 4
Career development Workshop – Applying My Knowledge.
—   Jeff Standish, ACS

(no downloads)

Session 5
Introduction and concepts
— David Stranz, ‎Sierra Analytics

An Enterprise Informatics Platform for Nontargeted Mass Spectrometry-Based Metabolomics
— Hua Xu, PepsiCo

A New, Easy, and Accurate Way to Predict Chromatographic Retention (and Other Free Tools)
— Paul G. Boswell,Horticultural Science and the Microbial and Plant Genomics Institute, University of Minnesota

Application of sub-2µm particle CO2-based chromatography coupled to mass spectrometry for comprehensive and targeted lipidomics.
— Vladimir Shulaev, University of North Texas
Presentation sponsored by Waters Centers of Innovation

Session 6
Decoding Food Chemistry: Flavor to Health
— Devin Peterson, Food Research and Education Center, University of Minnesota
Presentation sponsored by Waters Centers of Innovation

Molecular Weight Profiling and Component Analysis in Algal Oil
— Greg McAlpin, Sapphire Energy, Inc.

Session 7
Wisdom of the Crowd – Cross linked Pyridine Phase
— William Farrell, Pfizer

Session 8
New Developments in Drug Degradation
— Karen Alsante, Pfizer, Steve Baertschi, Lilly

Integrating Predictive and Experimental Tools to Capture Degradation Knowledge in the Early Development Phase of a Drug’s Lifetime
— Tasneem Patwa, Pfizer Pharma Therapeutics Research & Development

Interesting Solution and Solid State Oxidative Degradation Chemistry of an Alkyl Substituted Phenol Drug Molecule
— Chris Foti, Pfizer PharmaTherapeutics Research & Development

Exploring the phenomenon of selective quenching of undesired reactive oxygen species (ROS) in autoxidative stress testing
— Michael Watkins, Eli Lilly and Company

Session 9

Preliminary Investigation of the Mechanism of Degradation of a Poorly Crystallized Drug Substance in the Solid-State
— Biren Joshi, GlaxoSmithKline

Forced Degradation Study of BMS-582664, an Investigational Active Pharmaceutical Ingredient for the Treatment of Cancer
— Yande Huang, Analytical & Bioanalytical Development Bristol-Myers Squibb

Control of Genotoxic Degradation Products – A Case Study for a Heptatitis C Antiviral Candidate
— Gregory W. Sluggett, Pfizer PharmaTherapeutics Research & Development

Session 10
Emerging technologies
— Michael Balogh, Waters, Guest Chair: Charles N. McEwen, University of the Sciences

Ion Mobility Spectrometry for Rapid At-Line Cleaning Verification Testing using a Prototype Instrument Equipped with a High Capacity Ionization Source
— Mark Strege, Sr. Research Scientist, Eli Lilly & Co.

Novel Applications of Direct Analysis in Real Time (DART) MS in Pharmaceutical Industry
— Guilong Charles Cheng, Pfizer Analytical R&D

Matrix- and Solvent-Assisted Ionization of Small and Large Molecules without High Voltage, a Laser, or Heat and Capable of High Throughput
— Sarah Trimpin, Wayne State University
Presentation sponsored by Waters Centers of Innovation

Session 11
Emerging Applications Using SFC
— William Farrell, Pfizer, Guest chair: Christine Aurigemma, Oncology Medicinal Chemistry,Pfizer Global R&D, La Jolla

On-Line coupling of supercritical fluid extraction with supercritical fluid chromatography for chiral separation of racemic mixture containing insoluble impurities
— Kyung H. Gahm, Amgen, Inc.

Suitability of SFC in a DMPK Laboratory
— Amanda Culp, DMPK, GlaxoSmithKline

On the Horizon-A Look at Unique Applications in SFC
— William P. Farrell, Pfizer, Inc., La Jolla Laboratories